In today’s aesthetic landscape, skin treatments are no longer focused on just temporarily filling wrinkles and fine lines, but on restoring the skin structure from within.
Ellansé has become one of the trending innovations in 2026, combining two key benefits in one treatment: immediate volume restoration and wrinkle correction, along with long-term stimulation of collagen production beneath the skin—lasting up to 4 years.
The result is firmer, more elastic, and healthier-looking skin, with naturally enhanced facial contours. What Is Ellansé? How It Works, How It Differs from Fillers, and Who It’s Suitable For In this article, LINNA Clinic will guide you through everything you need to know.
Table of Contents
What Is Ellansé?
Ellansé is a dermal filler in the collagen biostimulator category, designed to provide immediate volume enhancement while also stimulating long-term collagen production beneath the skin.
It was first introduced to the global aesthetic market in 2009 by Sinclair Pharma from the United Kingdom and has received international certifications, including CE Mark, KFDA, and approval from the Thai FDA.
Ellansé is composed of two key components:
70% Carboxymethyl Cellulose (CMC), a gel carrier that helps evenly distribute PCL microspheres within the skin while providing immediate volume and wrinkle correction
30% Polycaprolactone (PCL) Microspheres, a biodegradable synthetic material that gradually stimulates the skin to produce new collagen over time
This combination allows physicians to use Ellansé for facial contouring and skin rejuvenation, helping the skin appear firmer, more elastic, and naturally youthful. Visible results typically develop within 3–6 months and can last between 1–4 years, depending on skin condition, product type, and individual aftercare.
How Does Ellansé Work?
Ellansé works through a dual-action mechanism, combining immediate results with long-term skin regeneration:
- Immediate Volume Restoration
After injection, the Carboxymethylcellulose (CMC) gel provides structural support and instantly fills volume loss beneath the skin. This helps enhance facial contours and soften wrinkles and folds in areas such as the forehead, temples, nasolabial folds, marionette lines, jawline, and chin. The gel gradually dissolves within 2–3 months. - Collagen Stimulation
The Polycaprolactone (PCL) Microspheres, which are small, smooth, and stable particles (25–50 micrometers), are evenly distributed within the CMC gel. These particles stimulate fibroblast cells to continuously produce Type I and Type III collagen, as well as elastin, following the body’s natural process. This leads to firmer skin, improved elasticity, and a smoother appearance with refined pores.
Although both CMC and PCL microspheres gradually biodegrade over time, the newly formed collagen structure remains, providing long-lasting results of 1–4 years, depending on the treatment area and individual care.
How Is Ellansé Different from Fillers?
Conventional dermal fillers, such as Hyaluronic Acid (HA fillers), primarily focus on filling wrinkles and adding volume by utilizing HA’s ability to retain water. This provides immediate and noticeable results. However, once the substance gradually breaks down (typically within 6–18 months, depending on the type of filler used), the results diminish over time and require repeat treatments.
Ellansé, on the other hand, differs in several key aspects:
- Different core components:
Unlike traditional HA fillers, Ellansé does not contain hyaluronic acid. Instead, it uses CMC gel and PCL microspheres, which are biocompatible polymers that can naturally degrade and also stimulate collagen production beneath the skin - Mechanism of action:
Ellansé functions as a collagen biostimulator, meaning it not only provides temporary volume but also promotes the formation of new collagen under the skin - Longer-lasting results:
Even after the main components gradually break down, the newly formed collagen structure remains. This helps maintain skin firmness, elasticity, and a youthful appearance for 1–4 years, which is longer compared to most traditional fillers
What Can Ellansé Help With?
- Filling deep lines and folds:
Such as nasolabial folds and marionette lines, helping the skin appear smoother and more youthful - Restoring volume in hollow areas:
Including temples, cheeks, and mid-face, improving facial fullness - Lifting and tightening sagging skin:
Enhancing facial contours, creating a fuller look, and improving jawline definition - Improving overall skin quality:
By stimulating new collagen production, the skin appears plumper, more elastic, and pores may look refined - Enhancing facial balance:
Helping to create harmonious facial proportions without surgery and without visible scars
How Many Types of Ellansé Are There and How Long Do They Last?
Ellansé is available in four different versions, designed to suit individual needs and skin conditions. Each type differs in the degradation rate of PCL microspheres, which directly affects the duration of collagen stimulation:
- Ellansé S: lasts approximately 1 year
- Ellansé M: lasts approximately 2 years
- Ellansé L: lasts approximately 3 years
- Ellansé E: lasts approximately 4 years
The duration of results may vary depending on several factors, such as age, skin condition, injection technique, amount of product used, as well as lifestyle and individual skincare habits.
Who Is Ellansé Suitable For, and Who Should Avoid It?
Suitable Candidates for Ellansé
- Individuals with wrinkles and deep lines on the face
- ndividuals with sagging skin and reduced elasticity who want a lifting effect without surgery and with natural-looking results
- Individuals with enlarged pores or uneven skin texture
- Individuals with volume loss, such as hollow cheeks, temples, deep nasolabial folds, or marionette lines
- Individuals who prefer long-lasting results and do not want frequent treatments like some fillers
- Individuals who want skin rejuvenation and facial contouring in one treatment
- Individuals with a history of allergy to HA fillers who are looking for an alternative option
Who Should Avoid Ellansé or Consult a Doctor Before Treatment?
- Pregnant or breastfeeding women
- Individuals with active infections, skin inflammation, or open wounds at the injection site (should wait until fully healed)
- Individuals with certain autoimmune conditions
- Individuals with bleeding disorders or difficulty with blood clotting
- Individuals with a history of allergy to any components of the product
Where Can Ellansé Be Injected and How Many cc Are Needed?
Ellansé is a versatile dermal filler that can address multiple skin concerns, including volume loss, wrinkles, facial contouring, and long-term collagen stimulation. Common treatment areas include:
- Forehead and between the eyebrows: Helps reduce forehead lines, correct brow drooping, and restore a more refreshed, youthful appearance
- Temples and cheeks: Restores volume in hollow areas, improving facial balance and contour
- Nasolabial folds and marionette lines: Fills deep lines, making the face appear smoother and more youthful
- Jawline: Helps lift and define the facial contour for a sharper appearance
- Chin: Enhances facial balance and proportion
- Back of the hands: Reduces the visibility of veins and tendons, making the hands appear smoother and more youthful
For the amount used, Ellansé typically starts at 2–3 cc per treatment area, with adjustments made based on the severity of volume loss or skin laxity in each individual case.
Is Ellansé Safe? Are There Any Side Effects?
Ellansé is considered a safe procedure when using authentic products and performed by an experienced physician. This is because its key component, PCL microspheres, is biocompatible and naturally biodegradable. It has also been used in medical applications for many years.
However, after injection, some temporary side effects may occur, such as swelling, redness, or bruising at the injection site. In rare cases, small lumps under the skin may develop (this is uncommon, especially when performed by an experienced doctor). Most of these effects are temporary and typically resolve within 1–3 days after treatment.
How Is Ellansé Different from Juvelook, Sculptra, and Radiesse?
Ellansé, Juvelook, Sculptra, and Radiesse are all classified as collagen biostimulators, meaning they help stimulate long-term collagen production beneath the skin. However, each product differs in its composition, mechanism of action, results, and treatment goals:
- Ellansé
Contains Polycaprolactone (PCL) microspheres in a Carboxymethylcellulose (CMC) gel. Its key advantage is a dual-action effect—providing immediate volume while continuously stimulating collagen production. Results can last 1–4 years (depending on the version used). It is suitable for facial contouring, restoring volume in areas such as temples, cheeks, and nasolabial folds, while also improving skin firmness in one treatment. Long-lasting results reduce the need for frequent touch-ups - Juvelook
Made of Poly D,L-lactic acid (PDLLA) combined with Hyaluronic Acid (HA). The HA provides immediate hydration and plumping, while PDLLA gradually stimulates collagen over time. It is mainly used for improving overall skin quality, such as acne scars, enlarged pores, uneven texture, and fine lines, rather than adding volume or reshaping facial structure. Results typically last 12–18 months - Sculptra
Contains Poly-L-lactic acid (PLLA) and focuses on gradual collagen stimulation. Results usually begin to appear within 1–3 months as the body produces new collagen. It is suitable for individuals with volume loss, sagging skin, or a tired appearance due to age-related collagen depletion. It addresses the underlying cause rather than just temporary filling, with results lasting up to 2 years - Radiesse
Contains Calcium Hydroxylapatite (CaHA) microspheres in a sodium carboxymethylcellulose gel. It provides both immediate volume and continuous stimulation of Type I and III collagen and elastin. Its strength lies in lifting and contouring, especially for areas like the jawline, chin, and facial structure that require definition. It can also improve skin quality in certain areas. Results typically last 12–18 months
The choice of product depends on individual skin concerns and treatment goals. A qualified physician will assess and recommend the most suitable option for each person.
Pre- and Post-Treatment Care for Ellansé
Pre-Treatment Preparation
- Avoid medications and supplements that affect blood clotting, such as aspirin, vitamin E, and fish oil, for at least 1 week
- Avoid smoking and alcohol for 24–48 hours to help reduce the risk of bruising or swelling after the injection
- Avoid exfoliating products, scrubs, waxing, and laser treatments for at least 3–7 days
- Get adequate rest, with at least 6–8 hours of sleep, to prepare your body
- Inform your doctor of your medical history and any allergies in detail for proper risk assessment
Post-Treatment Care
- Avoid pressing, massaging, or touching the treated area for the first 1–2 days
- Avoid strenuous exercise or activities that increase blood circulation for 24–48 hours
- Avoid heat exposure, such as saunas, steam rooms, hot baths, and heat-based treatments, for at least 2 weeks, and apply sunscreen with a high SPF daily
- Avoid alcohol and smoking for 1–2 days
- Stay hydrated by drinking at least 1–2 liters of water, eat a healthy diet, and get sufficient rest
- If you experience unusual symptoms such as excessive redness, swelling, severe pain, skin discoloration, fever, or chills, consult a doctor immediately
Summary
Ellansé is a dermal filler that combines immediate volume enhancement with long-term collagen stimulation, providing both short-term and long-term results. It is suitable for individuals who want facial contouring, skin lifting, and overall skin rejuvenation from within. Results can last between 1–4 years, depending on individual factors.
For safe and optimal outcomes, Ellansé should be performed by an experienced physician, with a thorough facial assessment to ensure natural-looking, balanced, and personalized results.
If you are looking for a solution to enhance facial contours, fill deep lines, and restore youthful skin naturally with collagen-stimulating technology like Ellansé, LINNA Clinic offers personalized treatments under the care of experienced doctors. Each treatment plan is tailored based on individual facial structure and goals to ensure safe and effective results.
For more information, please contact:
Call: 063-609-8888 | WhatsApp: +66 919799554 | LINE: @linnaclinic
