
The vascular system is one of the body's essential structures. It is responsible for transporting blood, oxygen, and nutrients to various organs so that the body can function normally.
However, as we age, together with certain contributing factors, the vascular system may begin to deteriorate, become inflamed, or develop abnormal blood circulation. This may increase the risk of vascular diseases such as coronary artery disease, cerebrovascular disease, and aneurysm.
With advancements in medical technology and Regenerative Medicine, new approaches have increasingly been developed to support vascular health.
Mesenchymal Stem Cells (MSCs), which are stem cells with the ability to support the repair and regeneration of damaged tissues, have been studied and developed for use in supporting vascular and circulatory-system recovery.
This has led to the development of Vasculogenic MSC, a type of stem cell with the potential to develop into cells related to the vascular system and to support the formation of new blood vessels within the body.
What is Vasculogenic MSC? Who may be suitable for it? What are its advantages and important considerations? Is Vasculogenic MSC safe?
This article from LINNA Clinic provides the answers.
What Is Vasculogenic MSC?
Vasculogenic MSC is a type of stem cell, or Mesenchymal Stem Cell, with the potential to develop into cells involved in the formation or support of blood vessels, such as endothelial cells and pericytes. These cells play an important role in the formation and maintenance of tissues, including organs related to the circulatory system such as the heart, brain, kidneys, and most organs in the body that depend on blood vessels for their blood supply.
Key Properties of Vasculogenic MSC
Vasculogenic MSC has several properties that may help support vascular-system recovery, including:
- Supports vascular-function recovery: Helps repair blood vessels that have deteriorated or become damaged, supporting better balance and function of the circulatory system and helping reduce disease severity.
- Stimulates new blood-vessel formation: Vasculogenic MSC can stimulate angiogenesis, helping support the formation of new blood vessels so that tissues can receive more oxygen and nutrients.
- Helps improve blood circulation: When the vascular system functions more efficiently, blood can circulate more effectively to important organs such as the brain, heart, and muscles, contributing positively to overall health.
- Supports recovery of tissues related to the vascular system: By stimulating the repair of tissues damaged by different factors, it may help slow the degeneration of vascular cells.
Who May Be Suitable for Vasculogenic MSC?
Vascular recovery with Vasculogenic MSC may be considered for individuals with the following health concerns:
- Individuals who want to support the repair and formation of new blood vessels in the body.
- Individuals with anemia. In a case study involving a 46-year-old female patient with anemia together with a low white-blood-cell count (low WBC and Hb 8 g/dL), after receiving MSC at a dose of 1 million cells/kg for approximately 2 months, the white-blood-cell count showed a trend toward returning to the normal range. Hemoglobin levels increased, red-blood-cell (RBC) count and Hematocrit improved, blood-cell Morphology became closer to normal, and markers of inflammation in the body showed a decreasing trend.
- Patients with abnormalities related to blood-vessel constriction.
- Individuals with high levels of fat accumulation in the blood vessels.
- Individuals with symptoms related to vascular degeneration, such as vascular stenosis, cardiovascular disease, diabetes, and hypertension.
- Individuals with abnormal blood-vessel hardening or clotting-related conditions.
- Individuals at risk of paralysis or stroke.
- Individuals with inflammation in the body. In a case study involving a 41-year-old female patient with health concerns and a high C-Reactive Protein level, after receiving MSC at a dose of 1 million cells/kg for approximately 1 month, hs-CRP decreased from 14.10 mg/L to less than 0.40 mg/L, which was within the normal range. This reflected a trend toward reduced Systemic Inflammation.
Those interested in the service should consult a physician so that individual risks and suitability can be evaluated.
Advantages of Vasculogenic MSC
- Intravenous administration of Vasculogenic MSC (IV Drip) helps stimulate the body's natural vascular and circulatory recovery processes. It may support recovery after vascular disease and help slow long-term degeneration of the circulatory system.
- Helps support the function of important organs that depend on the vascular system, such as the heart, kidneys, and brain, contributing positively to overall health.
- Vasculogenic MSC by IV Drip is a relatively straightforward procedure that takes approximately 20-30 minutes. Afterward, patients can return to their normal daily activities without needing to recover at the clinic.
- Vasculogenic MSC derived from umbilical-cord tissue has a favorable safety profile and tends to have low immunogenicity because the cells are at an early stage of life and have less cellular damage compared with cells derived from adult tissues. The cells also undergo strict donor screening and quality-control procedures in a standardized laboratory.
- It can be combined with other medical treatments or health-recovery approaches to further support vascular and circulatory recovery. However, this approach should be performed only under close supervision by an experienced physician.
Important Things to Know About Vasculogenic MSC
- Responses and results after the procedure may vary depending on several factors, including age, severity of the condition, other underlying diseases, and individual self-care.
- Vasculogenic MSC is only an approach intended to support recovery of the vascular and circulatory systems and help them function more effectively. It is not a treatment for disease and cannot replace standard medical treatment.
- The procedure must be carried out under the supervision of an experienced physician with strict quality control at every stage, including physical-readiness assessment, quality of the cells used, method of cell administration, and post-treatment follow-up.
- Vasculogenic MSC performed in a standard-compliant clinic by an experienced physician is considered a safe procedure. However, temporary side effects may occur, such as pain or swelling at the cell-administration site, fatigue, or low-grade fever. In general, these symptoms resolve naturally within 1-3 days.
How Often Should Vasculogenic MSC Be Done?
In general, intravenous Vasculogenic MSC (IV Drip) is individualized. The number of cells and treatment frequency are determined according to factors such as age, body weight, severity of symptoms, and recovery goals.
- General adults / older adults who want vascular-system recovery: Vasculogenic MSC3-0.5 million cells/kg every 6 months, or UMSC 1 million cells/kg + Vasculogenic MSC 20-50 million cells (depending on budget and body weight) every 6 months. Treatment can be repeated every 3-6 months, with follow-up appointments every 3 months.
- Patients with Stroke, cardiovascular conditions, or diabetes with chronic wounds: UMSC 1 million cells/kg + Vasculogenic MSC 20-50 million cells (depending on budget and body weight) every 6 months, with follow-up appointments every 1 month.
- Individuals with cognitive decline due to Stroke or ischemic heart disease / coronary artery stenosis: Neurogenic MSC3-0.5 million cells/kg + Vasculogenic MSC 0.3-0.5 million cells/kg. Physicians often recommend beginning care during the Golden Period, or within the first 3 months after the onset of symptoms, and treatment may be repeated every 3-6 months.
Recovery with Vasculogenic MSC must be performed under the supervision of an experienced physician, with assessment and adjustment of the treatment plan according to each individual's physical condition.
Is Vasculogenic MSC Dangerous?
In general, administration of Mesenchymal Stem Cells, including Vasculogenic MSC, is considered a safe process when performed under the supervision of an experienced physician and when the selected cells have undergone strict quality control, contamination testing, and safety assessment regarding risks such as tumor or cancer formation.
However, Stem Cell therapy is still considered a Regenerative Medicine approach that requires continued study. Therefore, anyone interested should undergo a detailed health assessment before treatment to ensure that the approach is appropriate and safe for the individual.
How to Take Care of Yourself Before and After Receiving Vasculogenic MSC
Before Receiving Vasculogenic MSC
- Consult a physician for a physical assessment before treatment. The physician will review health history, underlying conditions, and perform blood tests as appropriate for each case.
- Get sufficient rest, at least 6-8 hours, to prepare the body.
- Drink enough clean water and eat nutritious foods.
- Avoid alcohol and smoking for at least 1 week.
- Take care to avoid injury, physical impact, or wounds. Avoid other procedures such as Filler injections, Bo programs, liposuction, or laser treatments for at least 1-2 weeks.
After Receiving Vasculogenic MSC
- Get adequate rest during the first 1-2 days.
- Drink more clean water to help the body recover.
- Avoid strenuous exercise during the first 24-48 hours.
- Avoid injury, wounds, abrasions, or physical impact to the area where the cells were administered for at least 2 weeks.
- Avoid smoking and alcohol for at least 1 week.
- Attend follow-up appointments with the physician as scheduled. If any abnormal symptoms occur, seek medical attention immediately.
Summary
Vasculogenic MSC is a type of stem cell with the potential to support vascular-system recovery by helping stimulate the formation of new blood vessels and supporting the repair of damaged blood vessels. This may help the circulatory system function more effectively. The approach is therefore another option in Regenerative Medicine for individuals who want to support vascular health, blood circulation, and important organs throughout the body. For appropriate and safe outcomes, treatment should be carried out under the supervision of an experienced physician in a standard-compliant medical facility.
If you are looking for an approach to support vascular health, restore the circulatory system, or are interested in Regenerative Medicine using Vasculogenic MSC stem cells, LINNA Clinic provides care under the supervision of a medical team. Health assessments and individualized treatment planning are provided to support appropriate results and each patient's health goals. Contact: 063-609-8888, WhatsApp +66 919799554 or LINE: @linnaclinic
References
- Case Study: ภาวะโลหิตจางและเม็ดเลือดขาวต่ำที่ตอบสนองต่อการรักษาด้วย Mesenchymal Stem Cells (MSC)
- Case Study: การใช้ Mesenchymal Stem Cells (MSC) เพื่อลดอาการอักเสบในผู้ที่มีค่า C-Reactive Protein สูง
This article has been prepared and reviewed by the LINNA Clinic medical team.
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