In an era when skincare is no longer limited to temporarily filling and softening deep lines, but also focuses on restoring the skin’s underlying structure from within, Ellansé has become one of the leading skin-rejuvenation innovations of 2026.
Ellansé combines two benefits in one treatment: it immediately fills deep lines and restores facial volume while continuously stimulating collagen production beneath the skin for up to four years. The result is firmer, more elastic, healthier-looking skin and naturally balanced facial contours.
What is Ellansé? Is it really effective? How is it different from conventional fillers, and who is it suitable for? This article from LINNA Clinic explains everything you should know in detail.
What Is Ellansé?
Ellansé is a dermal filler in the Collagen Biostimulator category. It is designed to restore volume immediately while stimulating long-term collagen production beneath the skin.
Ellansé was first introduced to the global aesthetics market in 2009 by Sinclair Pharma, a company from the United Kingdom. It has received internationally recognized certifications, including the CE Mark, KFDA approval, and approval from the Thai Food and Drug Administration.
Ellansé contains two key components:
- 70% Carboxymethylcellulose (CMC): A water-based gel that acts as a Gel Carrier, helping the PCL Microspheres distribute evenly beneath the skin. It also immediately fills deep lines and restores volume after injection.
- 30% Polycaprolactone (PCL) Microspheres: A synthetic, biodegradable biomaterial that naturally breaks down in the body. It plays an important role in continuously stimulating skin cells to produce new collagen.
Doctors commonly use Ellansé for facial contouring and skin rejuvenation. It helps the skin appear firmer, tighter, more elastic, and naturally youthful. Noticeable results generally begin to develop within 3–6 months and may last for 1–4 years, depending on the patient’s skin condition, the Ellansé product type used, and individual aftercare.
How Does Ellansé Work?
Ellansé works through two complementary mechanisms, known as Dual-Action: immediate volume restoration after injection and long-term skin rejuvenation.
- Immediate filling effect: After Ellansé is injected into the skin, the Carboxymethylcellulose (CMC) gel immediately supports the skin’s structure and fills spaces beneath the skin. This gives the face more volume and dimension while visibly softening wrinkles and deep lines in areas such as the forehead, between the eyebrows, temples, nasolabial folds, marionette lines, jawline, and chin. The CMC gel then gradually breaks down over approximately 2–3 months.
- Collagen stimulation: Polycaprolactone (PCL) Microspheres are small, smooth, highly stable spherical particles measuring approximately 25–50 micrometers. These particles are evenly suspended in the CMC gel and stimulate fibroblasts to produce Type I and Type III collagen, as well as elastin, continuously through the body’s natural processes. This helps make the skin firmer and more elastic while reducing the appearance of enlarged pores.
Although the CMC gel and PCL Microspheres gradually break down completely over time, the newly formed collagen structure beneath the skin remains. Results may last for 1–4 years, depending on the injection area and each patient’s aftercare.
How Is Ellansé Different from Conventional Fillers?
Conventional dermal fillers, such as Hyaluronic Acid fillers or HA Fillers, primarily fill deep lines and restore volume through HA’s ability to retain water. They produce visible and immediate results.
However, when the active ingredient breaks down—usually within approximately 6–18 months, depending on the filler used—the results gradually diminish, and repeat injections may be required.
Ellansé differs from conventional fillers in the following ways:
- Its main ingredients are not Hyaluronic Acid (HA): Unlike conventional fillers, Ellansé contains CMC gel and PCL Microspheres. These small polymer particles are biocompatible, naturally biodegradable, and capable of stimulating collagen production beneath the skin.
- Its mechanism of action: Ellansé is a Collagen Biostimulator. It does not only provide temporary volume but also stimulates the formation of new collagen beneath the skin.
- Longer-lasting results than conventional fillers: Even after the main ingredients gradually break down, the newly produced collagen structure remains, helping the skin look firmer, more elastic, and youthful for approximately 1–4 years.
What Can Ellansé Help Improve?
- Fills deep lines, including nasolabial folds and marionette lines, helping the face appear smoother and more youthful.
- Restores volume in hollow areas, such as the temples, cheeks, and nasolabial folds.
- Lifts and firms sagging skin, helping the face look fuller and the facial contour appear more defined.
- Improves overall skin quality by stimulating new collagen production, making the skin appear plumper and more elastic while reducing the appearance of enlarged pores.
- Balances and contours the face without surgery or surgical scars.
How Many Types of Ellansé Are Available and How Long Do They Last?
Ellansé was designed in four versions to accommodate different individual needs and skin conditions. Each version differs in the degradation time of its PCL Microspheres, which directly affects the duration of collagen stimulation:
- Ellansé S lasts approximately 1 year.
- Ellansé M lasts approximately 2 years.
- Ellansé L lasts approximately 3 years.
- Ellansé E lasts approximately 4 years.
The duration of results may vary depending on several factors, including the patient’s age and skin condition, the amount of product used, the doctor’s injection technique, lifestyle habits, and individual skincare practices.
Who Is Ellansé Suitable For and Who Should Avoid It?
People Who May Be Suitable for Ellansé
- People with wrinkles and deep facial lines.
- People with sagging or inelastic skin who want to lift and firm the face without surgery while maintaining natural-looking results.
- People with enlarged pores or uneven skin texture.
- People with facial volume loss, such as hollow cheeks, hollow temples, deep nasolabial folds, or marionette lines.
- People who want longer-lasting results and do not want frequent repeat injections like those required with certain conventional fillers.
- People who want to rejuvenate the skin from within while contouring the face in the same treatment.
- People with a previous history of allergic reactions to HA fillers who are looking for another option to restore facial volume.
People Who Should Avoid Ellansé or Consult a Doctor for a Risk Assessment Before Treatment
- Pregnant or breastfeeding women.
- People with an infection, inflamed skin, or an open wound in the intended injection area. Treatment should be postponed until the area has fully healed.
- People with certain immune-system disorders.
- People with abnormal bleeding or difficulty stopping bleeding.
- People with a previous history of allergy to any ingredient in the product.
Where Can Ellansé Be Injected and How Many cc Are Required?
Ellansé is a dermal filler that can help address various concerns, including restoring skin volume, softening wrinkles, improving facial structure, and continuously stimulating collagen production.
Common injection areas include:
- Forehead and between the eyebrows: Helps soften forehead wrinkles, improve the appearance of drooping eyebrows, restore facial brightness, and create a more youthful appearance.
- Temples and cheeks: Restores volume in hollow cheeks and temples, helping create more balanced and attractive facial dimensions.
- Nasolabial folds and marionette lines: Fills deep lines to help the face appear younger and more refreshed.
- Jawline: Helps lift and firm the skin while making the facial contour appear sharper and more defined.
- Chin: Improves facial balance and helps create more proportionate facial contours.
- Backs of the hands: Reduces the visibility of veins and tendons, helping the hands appear fuller, smoother, and more youthful.
The amount of Ellansé used generally begins at approximately 2–3 cc per treatment area. The amount may be increased as appropriate in patients with significant volume loss or skin laxity.
Is Ellansé Dangerous and What Are the Possible Side Effects?
Ellansé is considered a safe procedure when genuine products are used and injections are performed by an experienced doctor.
Its key ingredient, PCL Microspheres, is biocompatible and naturally biodegradable. PCL has also been used for medical purposes for many years.
However, swelling, redness, or bruising may occur around the injection area after treatment. In some patients, small, firm lumps may develop beneath the skin, although this is very uncommon when injections are performed by an experienced doctor.
Most side effects are temporary and generally resolve naturally within 1–3 days after treatment.
How Is Ellansé Different from Juvelook, Sculptra, and Radiesse?
Ellansé, Juvelook, Sculptra, and Radiesse are all classified as Collagen Biostimulators. They share the ability to stimulate long-term collagen production beneath the skin.
However, each product differs in its main ingredients, mechanism of action, type of results, and intended uses:
- Ellansé: Its main ingredient is Polycaprolactone (PCL) Microspheres suspended in Carboxymethylcellulose (CMC) gel. Its key advantage is its two-stage effect: the gel immediately fills deep lines, while the PCL Microspheres continuously stimulate collagen production. Results last approximately 1–4 years, depending on the Ellansé version used. It is suitable for people who want to contour the face, fill the temples, nasolabial folds, or hollow cheeks, restore facial dimension, and firm the skin in a single treatment. Its long-lasting results reduce the need for frequent repeat treatments.
- Juvelook: Its main ingredients are Poly D,L-lactic acid (PDLLA) and Hyaluronic Acid (HA). HA helps hydrate the skin and creates a plumper appearance after treatment, while PDLLA gradually stimulates long-term collagen production. Juvelook is particularly suitable for improving overall skin quality, including acne scars, enlarged pores, uneven skin texture, and fine lines, rather than restoring significant volume or changing facial structure. Results generally last approximately 12–18 months.
- Sculptra: Its main ingredient is Poly-L-lactic acid (PLLA), which gradually stimulates collagen production. Results generally begin to appear within 1–3 months as the body starts producing new collagen. It is suitable for people with facial hollowness, sagging skin, or a tired-looking face caused by age-related collagen loss. Sculptra addresses the underlying cause of reduced skin quality rather than providing only temporary filling. Results can last for up to two years, reducing the need for frequent repeat treatment.
- Radiesse: Its main ingredient is Calcium Hydroxylapatite (CaHA) Microspheres suspended in Sodium Carboxymethylcellulose gel. It provides immediate filling while continuously stimulating Type I and Type III collagen and elastin production. Its key advantage is lifting and improving definition in areas such as the jawline, chin, and mandibular contour or other areas that require stronger structural support. It may also be used to improve skin quality in selected areas. Radiesse is suitable for people who want both volume and firmness, with results lasting approximately 12–18 months.
Product selection depends on each patient’s skin concerns and treatment goals. The doctor will assess the patient and make the treatment decision together with them.
How to Prepare Before Ellansé and How to Care for Yourself After Treatment
How to Prepare Before Ellansé Treatment
- Avoid medications and supplements that affect blood clotting, such as aspirin, vitamin E, and fish oil, for at least one week.
- Avoid smoking and alcohol for 24–48 hours to help reduce the risk of bruising or swelling after injection.
- Stop using exfoliating skincare products and avoid facial scrubs, waxing, and laser treatments for at least 3–7 days.
- Get sufficient rest and sleep for at least 6–8 hours to prepare the body for treatment.
- Inform the doctor of your complete medical history and any medication or substance allergies so that the risks can be assessed before the procedure.
How to Care for Yourself After Ellansé Treatment
- Avoid pressing, massaging, or touching the injection area during the first 1–2 days.
- Avoid strenuous exercise and activities that significantly increase blood circulation during the first 24–48 hours.
- Avoid heat exposure, including saunas, steam rooms, hot baths, and heat-based skin procedures, for at least the first two weeks. Apply sunscreen with a high SPF every day.
- Avoid alcohol and smoking for 1–2 days.
- Drink at least 1–2 liters of water, eat nutritious foods, and get sufficient rest.
- If unusual symptoms occur, including redness, swelling, unusually severe pain, skin discoloration, fever, or chills, seek medical attention immediately.
Summary
Ellansé is a dermal filler that combines immediate volume restoration and collagen stimulation in a single treatment, providing both short-term and long-term benefits.
It is suitable for people who want to contour the face, lift and firm the skin, and improve skin quality from within. Results may last for approximately 1–4 years, although individual outcomes may vary.
Ellansé injections should be performed under the supervision of an experienced doctor. A detailed facial assessment is necessary to create natural-looking, safe, and individually appropriate results.
If you are looking for an option to contour the face, fill deep lines, and naturally rejuvenate the skin using an innovative collagen stimulator such as Ellansé, LINNA Clinic provides treatment under the care of an experienced medical team.
Each patient receives a detailed facial-structure assessment and an individualized treatment plan to achieve suitable, safe results that directly address their needs.
For a consultation, contact 063-609-8888, WhatsApp +66 919799554, or LINE: @linnaclinic.
This article has been prepared and reviewed by the LINNA Clinic medical team.
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