EBOO PLUS Therapy: Supporting the Management of Chronic Inflammation from Within and NCDs

Chronic Inflammation is a condition in which the body’s immune system remains continuously activated over a prolonged period and is unable to return to its normal state of balance. This can result in persistent inflammation throughout the body and may lead to symptoms such as chronic fatigue, joint pain, muscle aches, increased susceptibility to infections, and slower recovery from illness or physical exertion.

If chronic inflammation continues without appropriate care, it may contribute to damage to cells and internal organs and may be associated with the development of various non-communicable diseases (NCDs), including cancer, cardiovascular disease, type 2 diabetes, autoimmune diseases, Alzheimer’s disease, and depression.

Causes of Chronic Inflammation in Everyday Life

Many people experience health concerns such as poor-quality sleep, persistent fatigue, itchy skin rashes, allergies, or frequent illness and may assume that these are only temporary problems. In reality, however, these symptoms may be signs of chronic inflammation that is gradually developing within the body and may be associated with NCDs, or non-communicable diseases, which can have a long-term impact on quality of life.

LINNA Clinic invites you to better understand what chronic inflammation is, what NCDs are, and which conditions fall into this category. Discover EBOO PLUS Therapy, an innovative approach designed to support the body’s recovery, promote healthy blood circulation, and help restore balance from within—an alternative approach to health care that supports quality longevity.

Warning Signs That Your Body May Be Experiencing Chronic Inflammation

Chronic inflammation may not cause obvious symptoms in its early stages, which means many people may not realize it is occurring or may mistake the signs for ordinary fatigue from daily life. Symptoms may become more noticeable or frequent over time, such as:

• Feeling tired or easily fatigued even after getting enough rest
• Waking up feeling unrefreshed, having poor-quality sleep, or not sleeping deeply
• Frequent muscle aches or joint pain without a clear cause
• Slower recovery after strenuous physical activity or during periods of recuperation
• Becoming ill or developing infections more easily, or experiencing frequent fevers
• Recurrent rashes, itching, allergies, or skin irritation
• Brain fog, difficulty concentrating, or frequent mood changes
• Digestive disturbances, bloating, or irregular bowel movements
• Gaining weight easily, difficulty losing weight, or increased fat accumulation

These symptoms cannot be used to diagnose chronic inflammation on their own, but they are signs that should not be overlooked, particularly in people at higher risk, such as those with underlying medical conditions, overweight or obesity, high blood lipids, elevated blood sugar, or high blood pressure.

A comprehensive health assessment may help identify the underlying cause and support the development of an appropriate care plan.

NCDs (Non-Communicable Diseases), or chronic non-communicable diseases, are a group of conditions that are not caused by infections and cannot be transmitted directly from one person to another. They usually develop gradually over a long period, ranging from several months to many years, and result from a combination of factors, including unhealthy lifestyle habits, genetics, environmental influences, and increasing age.

One of the major concerns with NCDs is that they often do not cause obvious symptoms in the early stages. In many cases, symptoms only become noticeable after complications develop or when vital organs begin to function abnormally. Common groups of NCDs include:

• Cardiovascular diseases, such as high blood pressure, coronary artery disease, ischemic heart disease, heart failure, and stroke
• Diabetes, particularly type 2 diabetes
• Abdominal obesity and metabolic syndrome, which are important risk factors for developing other NCDs
• Certain types of cancer, such as lung cancer, breast cancer, stomach cancer, colorectal cancer, liver cancer, and cervical cancer
• Chronic respiratory diseases, such as chronic obstructive pulmonary disease (COPD), asthma, and emphysema
• Dementia and Alzheimer’s disease

EBOO PLUS Therapy may serve as a supportive health-care approach for people who are at risk of, or living with, non-communicable diseases (NCDs). The approach focuses on supporting factors that may be associated with disease development, such as chronic inflammation, oxidative stress, and impaired blood circulation. It uses a closed-loop blood-processing system combined with controlled levels of oxygen and medical ozone, with the aim of supporting blood circulation, the delivery of oxygen and essential substances to tissues, and overall physiological balance.

According to a 2024 literature review in the field of musculoskeletal disorders, Ozone Therapy may stimulate the body’s natural antioxidant defense systems, reduce the production of certain pro-inflammatory mediators, and help modulate oxidative stress, which is a factor that may be associated with the development of NCDs. The review also suggested that ozone therapy may support blood circulation and oxygen delivery to tissues (Jeyaraman et al., 2024).

These findings are consistent with a 2025 literature review that compiled data from several clinical studies and reported that Ozone Therapy may help reduce oxidative stress and support the body’s antioxidant defense systems in certain patient populations (Alimohammadi et al., 2025).

In addition, a cohort study involving 28 patients with Peripheral Artery Disease found improvements in several clinical outcomes among those who received EBOO, including skin ulcer healing, pain, itching, sensations of heaviness in the legs, and overall quality of life, compared with patients who received intravenous prostacyclin. However, the researchers did not observe a clear difference in arterial blood flow in the legs, suggesting that the reported improvements may have involved other mechanisms as well (Di Paolo et al., 2005).

It is important to understand, however, that EBOO PLUS Therapy is intended as a supportive approach to help promote the body’s recovery and physiological function. It is not a direct treatment for NCDs and should not replace standard medical treatment. Individuals with chronic inflammation or those who have been diagnosed with an NCD should consult a physician for an individualized assessment of their risks and an appropriate recovery and health-care plan.

In general, a physician may recommend EBOO PLUS Therapy approximately once a week for a course of 4–5 sessions to support the body’s recovery and help manage factors associated with chronic inflammation. After the initial course, maintenance sessions may be considered every 3–4 months, or at intervals appropriate for each individual case.

However, outcomes may vary from person to person depending on several factors, including baseline health status, the degree of inflammation, lifestyle habits, and post-treatment self-care. The appropriate frequency and number of sessions should therefore be determined by a physician based on an individualized health assessment.

Before undergoing EBOO PLUS Therapy, it is important to prepare your body appropriately to help ensure that the procedure can be carried out as safely and smoothly as possible. General recommendations include:

• Undergo a medical evaluation before treatment, including a review of your medical history, physical examination, and an individualized assessment of whether the therapy is appropriate for you.
• Inform your physician in detail about any underlying medical conditions, previous treatments, medications or supplements you take regularly, and any known allergies to medications or other substances.
• Get adequate rest, ideally 6–8 hours of sleep, and avoid strenuous physical activity before the procedure.
• Drink an adequate amount of water to support normal hydration and blood circulation.
• Avoid alcohol for at least 24–48 hours before treatment.
• If instructed by your treating physician, avoid taking vitamin C for 24 hours before treatment and resume it only according to the clinic’s or physician’s recommendations.
• If you have a fever, significant fatigue, or an acute infection, inform the medical team. Your appointment may need to be postponed until your condition has improved.

EBOO PLUS Therapy may be incorporated into a broader, physician-guided health and recovery plan alongside other interventions, such as Vitamin Drips, Exosome IV, or certain stem cell–based therapies. The appropriate combination depends on an individual’s baseline health, medical history, treatment goals, and the evidence and regulatory status of each therapy.

Vitamin Drips involve the intravenous administration of vitamins, minerals, and other nutrients. Because these substances enter the bloodstream directly, IV supplementation may be considered when a physician identifies a specific nutritional need or when oral intake is inadequate. The formulation should be selected according to the individual’s health assessment rather than used routinely for everyone.

Exosome IV refers to the intravenous administration of exosome-based products. Exosomes are being studied for their potential role in cell-to-cell signaling and tissue-repair processes. However, clinical evidence, product quality, approved indications, and regulatory status vary considerably. Therefore, Exosome IV should only be considered after careful medical evaluation and confirmation that the product and its intended use comply with applicable regulations.

Stem Cell Therapy involves the use of stem cells or stem cell–derived products for specific medical purposes. Some stem cell treatments have established indications, while many applications promoted for general rejuvenation, anti-aging, chronic inflammation, or whole-body recovery remain investigational. Suitability depends on the type and source of cells, the medical condition being treated, available clinical evidence, and regulatory approval.

After EBOO PLUS Therapy, a physician may consider additional interventions when there is a specific clinical indication—for example, targeted IV nutrient supplementation when a deficiency or nutritional need has been identified. Exosome- or stem cell–based treatments require a more detailed evaluation of potential benefits, risks, supporting evidence, and regulatory status.

There is no single combination that is appropriate for everyone. The sequence, timing, and interval between therapies should be determined by a qualified physician based on the individual’s health status and treatment goals.