\u0644\u0645 \u062a\u0639\u062f \u0639\u0644\u0627\u062c\u0627\u062a \u0627\u0644\u0633\u0631\u0637\u0627\u0646 \u0641\u064a \u0627\u0644\u0648\u0642\u062a \u0627\u0644\u062d\u0627\u0644\u064a \u062a\u0642\u062a\u0635\u0631 \u0639\u0644\u0649 \u0627\u0644\u062c\u0631\u0627\u062d\u0629 \u0623\u0648 \u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0643\u064a\u0645\u064a\u0627\u0626\u064a \u0623\u0648 \u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0625\u0634\u0639\u0627\u0639\u064a \u0641\u0642\u0637\u060c \u0628\u0644 \u0623\u0635\u0628\u062d \u0647\u0646\u0627\u0643 \u0623\u064a\u0636\u0627\u064b \u0646\u0647\u062c \u0639\u0644\u0627\u062c\u064a \u064a\u064f\u0639\u0631\u0641 \u0628\u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0645\u0646\u0627\u0639\u064a (Immunotherapy)\u060c \u0648\u0627\u0644\u0630\u064a \u064a\u0631\u0643\u0632 \u0639\u0644\u0649 \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0642\u062f\u0631\u0629 \u0627\u0644\u062c\u0647\u0627\u0632 \u0627\u0644\u0645\u0646\u0627\u0639\u064a \u0641\u064a \u0627\u0644\u062c\u0633\u0645 \u0644\u0644\u0645\u0633\u0627\u0639\u062f\u0629 \u0641\u064a \u0645\u0647\u0627\u062c\u0645\u0629 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0633\u0631\u0637\u0627\u0646\u064a\u0629.\u0648\u0645\u0646 \u0623\u0628\u0631\u0632 \u0627\u0644\u0627\u0628\u062a\u0643\u0627\u0631\u0627\u062a \u0627\u0644\u062a\u064a \u062a\u062d\u0638\u0649 \u0628\u0627\u0647\u062a\u0645\u0627\u0645 \u0645\u0633\u062a\u0645\u0631 \u0641\u064a \u0627\u0644\u0645\u062c\u0627\u0644 \u0627\u0644\u0637\u0628\u064a \u0639\u0644\u0627\u062c \u0627\u0644\u062e\u0644\u0627\u064a\u0627 CAR-T. \u064a\u0639\u062a\u0645\u062f \u0647\u0630\u0627 \u0627\u0644\u0639\u0644\u0627\u062c \u0639\u0644\u0649 \u0623\u062e\u0630 \u0646\u0648\u0639 \u0645\u0646 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0645\u0646\u0627\u0639\u064a\u0629 \u064a\u064f\u0633\u0645\u0649 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062a\u0627\u0626\u064a\u0629 (T-cells) \u0645\u0646 \u062c\u0633\u0645 \u0627\u0644\u0645\u0631\u064a\u0636\u060c \u062b\u0645 \u062a\u0639\u062f\u064a\u0644\u0647\u0627 \u0648\u0631\u0627\u062b\u064a\u0627\u064b \u0644\u0645\u0633\u0627\u0639\u062f\u062a\u0647\u0627 \u0639\u0644\u0649 \u0627\u0644\u062a\u0639\u0631\u0641 \u0639\u0644\u0649 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0633\u0631\u0637\u0627\u0646\u064a\u0629 \u0627\u0644\u0645\u0633\u062a\u0647\u062f\u0641\u0629 \u0648\u0645\u0647\u0627\u062c\u0645\u062a\u0647\u0627 \u0628\u062f\u0642\u0629 \u0623\u0643\u0628\u0631.\u0648\u064a\u064f\u0639\u062f \u0639\u0644\u0627\u062c \u0627\u0644\u062e\u0644\u0627\u064a\u0627 CAR-T \u062e\u064a\u0627\u0631\u0627\u064b \u0639\u0644\u0627\u062c\u064a\u0627\u064b \u0625\u0636\u0627\u0641\u064a\u0627\u064b \u0644\u0628\u0639\u0636 \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u064a\u0646 \u0644\u0627 \u064a\u0633\u062a\u062c\u064a\u0628\u0648\u0646 \u0644\u0644\u0639\u0644\u0627\u062c\u0627\u062a \u0627\u0644\u062a\u0642\u0644\u064a\u062f\u064a\u0629\u060c \u0623\u0648 \u0627\u0644\u0630\u064a\u0646 \u0639\u0627\u062f\u062a \u0644\u062f\u064a\u0647\u0645 \u0627\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0627\u0644\u0645\u0631\u0636 \u0628\u0639\u062f \u0627\u0644\u0639\u0644\u0627\u062c.<\/p>
\u0648\u0645\u0639 \u0630\u0644\u0643\u060c \u0639\u0644\u0649 \u0627\u0644\u0631\u063a\u0645 \u0645\u0646 \u0623\u0646 \u0639\u0644\u0627\u062c \u0627\u0644\u062e\u0644\u0627\u064a\u0627 CAR-T \u064a\u064f\u0639\u062f \u062a\u0642\u062f\u0645\u0627\u064b \u0637\u0628\u064a\u0627\u064b \u0648\u0627\u0639\u062f\u0627\u064b \u0630\u0627 \u0625\u0645\u0643\u0627\u0646\u0627\u062a \u0639\u0627\u0644\u064a\u0629\u060c \u0641\u0625\u0646\u0647 \u0641\u064a \u0627\u0644\u0648\u0642\u062a \u0646\u0641\u0633\u0647 \u0639\u0645\u0644\u064a\u0629 \u0639\u0644\u0627\u062c\u064a\u0629 \u0645\u0639\u0642\u062f\u0629\u060c \u0648\u0644\u0647\u0627 \u0628\u0639\u0636 \u0627\u0644\u0642\u064a\u0648\u062f\u060c \u0648\u0642\u062f \u062a\u0633\u0628\u0628 \u0622\u062b\u0627\u0631\u0627\u064b \u062c\u0627\u0646\u0628\u064a\u0629 \u063a\u064a\u0631 \u0645\u0631\u063a\u0648\u0628\u0629. \u0644\u0630\u0644\u0643\u060c \u064a\u0646\u0628\u063a\u064a \u0639\u0644\u0649 \u0627\u0644\u0645\u0631\u0636\u0649 \u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u0645\u0639\u0644\u0648\u0645\u0627\u062a \u0645\u0646 \u062c\u0645\u064a\u0639 \u0627\u0644\u062c\u0648\u0627\u0646\u0628 \u0628\u0639\u0646\u0627\u064a\u0629 \u0642\u0628\u0644 \u0627\u062a\u062e\u0627\u0630 \u0627\u0644\u0642\u0631\u0627\u0631.\u0645\u0627 \u0647\u0648 \u0639\u0644\u0627\u062c \u0627\u0644\u062e\u0644\u0627\u064a\u0627 CAR-T\u061f \u0647\u0644 \u064a\u0645\u0643\u0646\u0647 \u062d\u0642\u0627\u064b \u0627\u0644\u0645\u0633\u0627\u0639\u062f\u0629 \u0641\u064a \u0639\u0644\u0627\u062c \u0627\u0644\u0633\u0631\u0637\u0627\u0646\u061f \u0648\u0645\u0627 \u0647\u064a \u0627\u0644\u0641\u0648\u0627\u0626\u062f \u0648\u0627\u0644\u0627\u062d\u062a\u064a\u0627\u0637\u0627\u062a \u0627\u0644\u062a\u064a \u064a\u062c\u0628 \u0645\u0639\u0631\u0641\u062a\u0647\u0627\u061f \u064a\u0642\u062f\u0651\u0645 \u0644\u0643\u0645 \u0647\u0630\u0627 \u0627\u0644\u0645\u0642\u0627\u0644 \u0645\u0646 LINNA Clinic \u0627\u0644\u0625\u062c\u0627\u0628\u0629. <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
\u0639\u0627\u062f\u0629\u064b\u060c \u062a\u064f\u0639\u062f \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062a\u0627\u0626\u064a\u0629 (T-cells) \u0646\u0648\u0639\u0627\u064b \u0645\u0646 \u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062f\u0645 \u0627\u0644\u0628\u064a\u0636\u0627\u0621 \u0627\u0644\u062a\u064a \u062a\u0644\u0639\u0628 \u062f\u0648\u0631\u0627\u064b \u0645\u0647\u0645\u0627\u064b \u0641\u064a \u062c\u0647\u0627\u0632 \u0627\u0644\u0645\u0646\u0627\u0639\u0629 \u0641\u064a \u0627\u0644\u062c\u0633\u0645. \u0648\u062a\u062a\u0645\u062b\u0644 \u0648\u0638\u064a\u0641\u062a\u0647\u0627 \u0641\u064a \u0627\u0643\u062a\u0634\u0627\u0641 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u063a\u064a\u0631 \u0627\u0644\u0637\u0628\u064a\u0639\u064a\u0629 \u0648\u0627\u0644\u062a\u062e\u0644\u0635 \u0645\u0646\u0647\u0627\u060c \u0645\u062b\u0644 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0645\u0635\u0627\u0628\u0629 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\u062a\u0637\u0648\u064a\u0631 \u0639\u0644\u0627\u062c \u0627\u0644\u062e\u0644\u0627\u064a\u0627 CAR-T\u060c \u0623\u0648 \u0645\u0627 \u064a\u064f\u0639\u0631\u0641 \u0628\u0627\u0633\u0645 \u0627\u0644\u0639\u0644\u0627\u062c \u0628\u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062a\u0627\u0626\u064a\u0629 \u0630\u0627\u062a \u0645\u0633\u062a\u0642\u0628\u0644\u0627\u062a \u0627\u0644\u0645\u0633\u062a\u0636\u062f\u0627\u062a \u0627\u0644\u062e\u064a\u0645\u0631\u064a\u0629 (Chimeric Antigen Receptor T-cell Therapy)\u060c \u0644\u0644\u0645\u0633\u0627\u0639\u062f\u0629 \u0641\u064a \u0627\u0644\u062a\u063a\u0644\u0628 \u0639\u0644\u0649 \u0647\u0630\u0627 \u0627\u0644\u062a\u062d\u062f\u064a. \u064a\u0639\u062a\u0645\u062f \u0647\u0630\u0627 \u0627\u0644\u0639\u0644\u0627\u062c \u0639\u0644\u0649 \u0623\u062e\u0630 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062a\u0627\u0626\u064a\u0629 \u0645\u0646 \u062c\u0633\u0645 \u0627\u0644\u0645\u0631\u064a\u0636\u060c \u0623\u0648 \u0645\u0646 \u0645\u062a\u0628\u0631\u0639 \u0645\u0646\u0627\u0633\u0628 \u0641\u064a \u0628\u0639\u0636 \u0627\u0644\u062d\u0627\u0644\u0627\u062a\u060c \u062b\u0645 \u062a\u0639\u062f\u064a\u0644\u0647\u0627 \u0641\u064a \u0627\u0644\u0645\u062e\u062a\u0628\u0631 \u0644\u062a\u0635\u0628\u062d \u062d\u0627\u0645\u0644\u0629 \u0644\u0645\u0633\u062a\u0642\u0628\u0644 \u062e\u0627\u0635 \u064a\u064f\u0633\u0645\u0649 CAR\u060c \u0623\u0648 \u0645\u0633\u062a\u0642\u0628\u0644 \u0627\u0644\u0645\u0633\u062a\u0636\u062f \u0627\u0644\u062e\u064a\u0645\u0631\u064a (Chimeric Antigen Receptor).\u064a\u0633\u0627\u0639\u062f \u0647\u0630\u0627 \u0627\u0644\u0645\u0633\u062a\u0642\u0628\u0644 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062a\u0627\u0626\u064a\u0629 \u0639\u0644\u0649 \u0627\u0644\u062a\u0639\u0631\u0641 \u0628\u062f\u0642\u0629 \u0623\u0643\u0628\u0631 \u0639\u0644\u0649 \u0627\u0644\u0645\u0633\u062a\u0636\u062f\u0627\u062a \u0627\u0644\u0645\u0633\u062a\u0647\u062f\u0641\u0629 \u0627\u0644\u0645\u0648\u062c\u0648\u062f\u0629 \u0639\u0644\u0649 \u0633\u0637\u062d \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0633\u0631\u0637\u0627\u0646\u064a\u0629 \u0648\u0627\u0644\u0627\u0631\u062a\u0628\u0627\u0637 \u0628\u0647\u0627. \u0628\u0639\u062f \u0630\u0644\u0643\u060c \u064a\u062a\u0645 \u0632\u0631\u0627\u0639\u0629 \u062e\u0644\u0627\u064a\u0627 CAR-T \u0648\u0632\u064a\u0627\u062f\u0629 \u0639\u062f\u062f\u0647\u0627 \u0641\u064a \u0627\u0644\u0645\u062e\u062a\u0628\u0631 \u062d\u062a\u0649 \u062a\u0635\u0628\u062d \u0643\u0627\u0641\u064a\u0629 \u0644\u0639\u0645\u0644\u064a\u0629 \u0627\u0644\u0639\u0644\u0627\u062c\u060c \u062b\u0645 \u062a\u064f\u0639\u0627\u062f \u0625\u0644\u0649 \u062c\u0633\u0645 \u0627\u0644\u0645\u0631\u064a\u0636 \u0639\u0646 \u0637\u0631\u064a\u0642 \u0627\u0644\u0648\u0631\u064a\u062f.<\/p>
\u0628\u0639\u062f \u062f\u062e\u0648\u0644 \u062e\u0644\u0627\u064a\u0627 CAR-T \u0625\u0644\u0649 \u0627\u0644\u062c\u0633\u0645\u060c \u062a\u0633\u062a\u062e\u062f\u0645 \u0647\u0630\u0647 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062c\u062f\u064a\u062f\u0629 \u0627\u0644\u0645\u0639\u062f\u0651\u0644\u0629 \u0645\u0633\u062a\u0642\u0628\u0644\u0627\u062a\u0647\u0627 \u0627\u0644\u062e\u0627\u0635\u0629 \u0644\u0644\u0628\u062d\u062b \u0639\u0646 \u0627\u0644\u0645\u0633\u062a\u0636\u062f\u0627\u062a \u0627\u0644\u0645\u062d\u062f\u062f\u0629 \u0627\u0644\u0645\u0648\u062c\u0648\u062f\u0629 \u0639\u0644\u0649 \u0633\u0637\u062d \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0633\u0631\u0637\u0627\u0646\u064a\u0629 \u0648\u0627\u0644\u0627\u0631\u062a\u0628\u0627\u0637 \u0628\u0647\u0627\u060c \u0645\u062b\u0644 CD19 \u0627\u0644\u0645\u0648\u062c\u0648\u062f \u0641\u064a \u0628\u0639\u0636 \u0623\u0646\u0648\u0627\u0639 \u0633\u0631\u0637\u0627\u0646\u0627\u062a \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0628\u0627\u0626\u064a\u0629\u060c \u0623\u0648 BCMA \u0627\u0644\u0645\u0648\u062c\u0648\u062f \u0641\u064a \u0645\u0631\u0636 \u0627\u0644\u0648\u0631\u0645 \u0627\u0644\u0646\u0642\u0648\u064a \u0627\u0644\u0645\u062a\u0639\u062f\u062f (Multiple Myeloma).\u0628\u0639\u062f \u0630\u0644\u0643\u060c \u062a\u0642\u0648\u0645 \u062e\u0644\u0627\u064a\u0627 CAR-T \u0628\u0625\u0641\u0631\u0627\u0632 \u0645\u0648\u0627\u062f \u0645\u0647\u0645\u0629 \u0645\u062b\u0644 Perforin \u0648 Granzyme \u0644\u0644\u0645\u0633\u0627\u0639\u062f\u0629 \u0641\u064a \u062a\u062f\u0645\u064a\u0631 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0633\u0631\u0637\u0627\u0646\u064a\u0629. \u0648\u0641\u064a \u0627\u0644\u0648\u0642\u062a \u0646\u0641\u0633\u0647\u060c \u062a\u0641\u0631\u0632 \u062e\u0644\u0627\u064a\u0627 CAR-T \u0627\u0644\u0633\u064a\u062a\u0648\u0643\u064a\u0646\u0627\u062a (Cytokines) \u0644\u0644\u0645\u0633\u0627\u0639\u062f\u0629 \u0641\u064a \u062a\u0646\u0634\u064a\u0637 \u0639\u0645\u0644 \u0627\u0644\u062c\u0647\u0627\u0632 \u0627\u0644\u0645\u0646\u0627\u0639\u064a\u060c \u0643\u0645\u0627 \u064a\u0645\u0643\u0646\u0647\u0627 \u0627\u0644\u062a\u0643\u0627\u062b\u0631 \u062f\u0627\u062e\u0644 \u0627\u0644\u062c\u0633\u0645 \u0644\u0641\u062a\u0631\u0629 \u0645\u0639\u064a\u0646\u0629. \u0644\u0630\u0644\u0643\u060c \u0642\u062f \u062a\u0633\u0627\u0639\u062f \u0641\u064a \u0627\u0644\u0633\u064a\u0637\u0631\u0629 \u0639\u0644\u0649 \u0627\u0644\u0645\u0631\u0636 \u0648\u0625\u0637\u0627\u0644\u0629 \u0645\u062f\u0629 \u0627\u0644\u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u0644\u0644\u0639\u0644\u0627\u062c \u0644\u062f\u0649 \u0628\u0639\u0636 \u0627\u0644\u0645\u0631\u0636\u0649.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
\u064a\u064f\u0639\u062f \u0639\u0644\u0627\u062c \u0627\u0644\u062e\u0644\u0627\u064a\u0627 CAR-T \u0623\u062d\u062f \u0627\u0644\u0623\u0633\u0627\u0644\u064a\u0628 \u0627\u0644\u062a\u064a \u064a\u0645\u0643\u0646 \u0623\u0646 \u062a\u0633\u0627\u0639\u062f \u0628\u0627\u0644\u0641\u0639\u0644 \u0641\u064a \u0639\u0644\u0627\u062c \u0628\u0639\u0636 \u0623\u0646\u0648\u0627\u0639 \u0627\u0644\u0633\u0631\u0637\u0627\u0646\u060c \u062e\u0627\u0635\u0629 \u0644\u062f\u0649 \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0645\u0635\u0627\u0628\u064a\u0646 \u0628\u0628\u0639\u0636 \u0633\u0631\u0637\u0627\u0646\u0627\u062a \u0627\u0644\u062f\u0645 \u0648\u0627\u0644\u0623\u0648\u0631\u0627\u0645 \u0627\u0644\u0644\u0645\u0641\u0627\u0648\u064a\u0629 \u0627\u0644\u0630\u064a\u0646 \u0644\u0627 \u064a\u0633\u062a\u062c\u064a\u0628\u0648\u0646 \u0644\u0644\u0639\u0644\u0627\u062c\u0627\u062a \u0627\u0644\u0642\u064a\u0627\u0633\u064a\u0629\u060c \u0623\u0648 \u0627\u0644\u0630\u064a\u0646 \u0639\u0627\u062f \u0644\u062f\u064a\u0647\u0645 \u0627\u0644\u0645\u0631\u0636 \u0628\u0639\u062f \u0627\u0644\u0639\u0644\u0627\u062c.\u0648\u0639\u0644\u0649 \u0627\u0644\u0631\u063a\u0645 \u0645\u0646 \u0623\u0646 \u0647\u0630\u0627 \u0627\u0644\u0639\u0644\u0627\u062c \u0644\u0627 \u064a\u0624\u062f\u064a \u0625\u0644\u0649 \u0627\u0644\u0634\u0641\u0627\u0621 \u0627\u0644\u062a\u0627\u0645 \u0641\u064a \u062c\u0645\u064a\u0639 \u0627\u0644\u062d\u0627\u0644\u0627\u062a\u060c \u0641\u0625\u0646 \u0627\u0644\u0623\u062f\u0644\u0629 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u062a\u0634\u064a\u0631 \u0625\u0644\u0649 \u0623\u0646 \u0628\u0639\u0636 \u0627\u0644\u0645\u0631\u0636\u0649 \u0642\u062f \u064a\u0633\u062a\u062c\u064a\u0628\u0648\u0646 \u0644\u0644\u0639\u0644\u0627\u062c \u0628\u0634\u0643\u0644 \u062c\u064a\u062f\u060c \u0648\u064a\u062f\u062e\u0644 \u0627\u0644\u0645\u0631\u0636 \u0644\u062f\u064a\u0647\u0645 \u0641\u064a \u0645\u0631\u062d\u0644\u0629 \u0627\u0644\u0647\u062f\u0648\u0621\u060c \u0648\u0642\u062f \u062a\u0633\u062a\u0645\u0631 \u0627\u0644\u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u0644\u0644\u0639\u0644\u0627\u062c \u0644\u0639\u062f\u0629 \u0633\u0646\u0648\u0627\u062a.<\/p>
\u0627\u0633\u062a\u0646\u0627\u062f\u0627\u064b \u0625\u0644\u0649 \u0646\u062a\u0627\u0626\u062c \u0627\u0644\u0645\u062a\u0627\u0628\u0639\u0629 \u0637\u0648\u064a\u0644\u0629 \u0627\u0644\u0645\u062f\u0649 \u0644\u062f\u0631\u0627\u0633\u0629 ZUMA-1 \u0644\u062f\u0649 \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0645\u0635\u0627\u0628\u064a\u0646 \u0628\u0627\u0644\u0648\u0631\u0645 \u0627\u0644\u0644\u0645\u0641\u0627\u0648\u064a \u0643\u0628\u064a\u0631 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0628\u0627\u0626\u064a\u0629 \u0627\u0644\u0645\u0642\u0627\u0648\u0645 \u0644\u0644\u0639\u0644\u0627\u062c\u060c \u0648\u064f\u062c\u062f \u0623\u0646 Axicabtagene Ciloleucel \u0623\u0648 Axi-cel \u0633\u0627\u0639\u062f \u0627\u0644\u0645\u0631\u0636\u0649 \u0639\u0644\u0649 \u062a\u062d\u0642\u064a\u0642 \u0645\u0639\u062f\u0644 \u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u0625\u062c\u0645\u0627\u0644\u064a \u0628\u0644\u063a 83% \u0648 \u0645\u0639\u062f\u0644 \u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u0643\u0627\u0645\u0644\u0629 \u0628\u0644\u063a 58%.\u0643\u0645\u0627 \u0627\u0633\u062a\u0645\u0631 \u0628\u0639\u0636 \u0627\u0644\u0645\u0631\u0636\u0649 \u0641\u064a \u0627\u0644\u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u0644\u0644\u0639\u0644\u0627\u062c \u0639\u0644\u0649 \u0627\u0644\u0645\u062f\u0649 \u0627\u0644\u0637\u0648\u064a\u0644 (Neelapu et al., 2023). \u0648\u0647\u0630\u0627 \u064a\u0634\u064a\u0631 \u0625\u0644\u0649 \u0623\u0646 \u0639\u0644\u0627\u062c \u0627\u0644\u062e\u0644\u0627\u064a\u0627 CAR-T \u0642\u062f \u064a\u0645\u062a\u0644\u0643 \u0627\u0644\u0642\u062f\u0631\u0629 \u0639\u0644\u0649 \u0627\u0644\u0633\u064a\u0637\u0631\u0629 \u0639\u0644\u0649 \u0627\u0644\u0645\u0631\u0636 \u0644\u0641\u062a\u0631\u0629 \u0637\u0648\u064a\u0644\u0629 \u0644\u062f\u0649 \u0628\u0639\u0636 \u0627\u0644\u0645\u0631\u0636\u0649.<\/p>
\u0648\u0641\u0642\u0627\u064b \u0644\u0628\u064a\u0627\u0646\u0627\u062a \u062f\u0631\u0627\u0633\u0629 ELIANA\u060c \u0627\u0644\u062a\u064a \u062a\u0627\u0628\u0639\u062a \u0627\u0644\u0645\u0631\u0636\u0649 \u0639\u0644\u0649 \u0627\u0644\u0645\u062f\u0649 \u0627\u0644\u0637\u0648\u064a\u0644 \u0644\u0645\u062f\u0629 \u062a\u0642\u0627\u0631\u0628 3 \u0633\u0646\u0648\u0627\u062a \u0644\u062f\u0649 \u0627\u0644\u0623\u0637\u0641\u0627\u0644 \u0648\u0627\u0644\u0634\u0628\u0627\u0628 \u0627\u0644\u0645\u0635\u0627\u0628\u064a\u0646 \u0628\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062f\u0645 \u0627\u0644\u0644\u064a\u0645\u0641\u0627\u0648\u064a \u0627\u0644\u062d\u0627\u062f \u0645\u0646 \u0646\u0648\u0639 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0628\u0627\u0626\u064a\u0629 B-cell Acute Lymphoblastic Leukemia (B-ALL)\u060c \u0633\u0648\u0627\u0621 \u0641\u064a \u0627\u0644\u062d\u0627\u0644\u0627\u062a \u0627\u0644\u062a\u064a \u0639\u0627\u062f\u062a \u0641\u064a\u0647\u0627 \u0627\u0644\u0625\u0635\u0627\u0628\u0629 \u0623\u0648 \u0644\u0645 \u062a\u0633\u062a\u062c\u0628 \u0644\u0644\u0639\u0644\u0627\u062c\u060c \u0648\u064f\u062c\u062f \u0623\u0646 Tisagenlecleucel \u0633\u0627\u0639\u062f \u0627\u0644\u0639\u062f\u064a\u062f \u0645\u0646 \u0627\u0644\u0645\u0631\u0636\u0649 \u0639\u0644\u0649 \u062f\u062e\u0648\u0644 \u0645\u0631\u062d\u0644\u0629 \u0647\u062f\u0648\u0621 \u0627\u0644\u0645\u0631\u0636.\u0643\u0645\u0627 \u0627\u0633\u062a\u0645\u0631 \u0628\u0639\u0636 \u0627\u0644\u0645\u0631\u0636\u0649 \u0641\u064a \u0627\u0644\u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u0644\u0644\u0639\u0644\u0627\u062c \u0644\u0639\u062f\u0629 \u0633\u0646\u0648\u0627\u062a (Laetsch et al., 2023).<\/p>
\u0648\u0641\u064a \u0627\u0644\u0645\u0642\u0627\u0628\u0644\u060c \u062a\u0634\u064a\u0631 \u0645\u0631\u0627\u062c\u0639\u0629 \u0627\u0644\u0628\u064a\u0627\u0646\u0627\u062a \u0637\u0648\u064a\u0644\u0629 \u0627\u0644\u0645\u062f\u0649 \u062d\u0648\u0644 \u0639\u0644\u0627\u062c \u0627\u0644\u062e\u0644\u0627\u064a\u0627 CAR-T \u0625\u0644\u0649 \u0623\u0646 \u062e\u0644\u0627\u064a\u0627 CAR-T \u0627\u0644\u062a\u064a \u062a\u0633\u062a\u0647\u062f\u0641 \u0645\u0633\u062a\u0636\u062f CD19 \u0642\u062f \u062a\u0633\u0627\u0639\u062f \u0628\u0639\u0636 \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0645\u0635\u0627\u0628\u064a\u0646 \u0628\u0633\u0631\u0637\u0627\u0646\u0627\u062a \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0628\u0627\u0626\u064a\u0629 \u0639\u0644\u0649 \u0627\u0644\u0648\u0635\u0648\u0644 \u0625\u0644\u0649 \u0645\u0631\u062d\u0644\u0629 \u0647\u062f\u0648\u0621 \u0627\u0644\u0645\u0631\u0636 \u0644\u0641\u062a\u0631\u0629 \u0637\u0648\u064a\u0644\u0629\u060c \u0648\u0642\u062f \u062a\u0645\u062a\u0644\u0643 \u0627\u0644\u0642\u062f\u0631\u0629 \u0639\u0644\u0649 \u062a\u062d\u0642\u064a\u0642 \u0627\u0644\u0634\u0641\u0627\u0621 \u0644\u062f\u0649 \u0628\u0639\u0636 \u0641\u0626\u0627\u062a \u0627\u0644\u0645\u0631\u0636\u0649.\u0648\u0645\u0639 \u0630\u0644\u0643\u060c \u0642\u062f \u062a\u062e\u062a\u0644\u0641 \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0645\u0646 \u0645\u0631\u064a\u0636 \u0644\u0622\u062e\u0631 \u0627\u0639\u062a\u0645\u0627\u062f\u0627\u064b \u0639\u0644\u0649 \u0639\u062f\u0629 \u0639\u0648\u0627\u0645\u0644. \u0623\u0645\u0627 \u062e\u0644\u0627\u064a\u0627 CAR-T \u0627\u0644\u062a\u064a \u062a\u0633\u062a\u0647\u062f\u0641 BCMA \u0644\u062f\u0649 \u0645\u0631\u0636\u0649 \u0627\u0644\u0648\u0631\u0645 \u0627\u0644\u0646\u0642\u0648\u064a \u0627\u0644\u0645\u062a\u0639\u062f\u062f (Multiple Myeloma)\u060c \u0641\u0639\u0644\u0649 \u0627\u0644\u0631\u063a\u0645 \u0645\u0646 \u0623\u0646\u0647\u0627 \u062a\u064f\u0638\u0647\u0631 \u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u0639\u0644\u0627\u062c\u064a\u0629 \u062c\u064a\u062f\u0629\u060c \u0641\u0625\u0646 \u0645\u062f\u0629 \u0647\u062f\u0648\u0621 \u0627\u0644\u0645\u0631\u0636 \u063a\u0627\u0644\u0628\u0627\u064b \u0645\u0627 \u062a\u0643\u0648\u0646 \u0623\u0642\u0635\u0631 \u0645\u0642\u0627\u0631\u0646\u0629\u064b \u0628\u0639\u0644\u0627\u062c CD19 CAR-T \u0627\u0644\u0645\u0633\u062a\u062e\u062f\u0645 \u0641\u064a \u0633\u0631\u0637\u0627\u0646\u0627\u062a \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0628\u0627\u0626\u064a\u0629 (Cappell & Kochenderfer, 2023).<\/p>
\u0644\u0630\u0644\u0643\u060c \u064a\u0645\u0643\u0646 \u0627\u0644\u0642\u0648\u0644 \u0625\u0646 \u0639\u0644\u0627\u062c \u0627\u0644\u062e\u0644\u0627\u064a\u0627 CAR-T \u064a\u064f\u0639\u062f \u062e\u064a\u0627\u0631\u0627\u064b \u0639\u0644\u0627\u062c\u064a\u0627\u064b \u0625\u0636\u0627\u0641\u064a\u0627\u064b \u0644\u0628\u0639\u0636 \u0623\u0646\u0648\u0627\u0639 \u0627\u0644\u0633\u0631\u0637\u0627\u0646. \u0648\u0642\u062f \u064a\u0645\u062a\u0644\u0643 \u0627\u0644\u0642\u062f\u0631\u0629 \u0639\u0644\u0649 \u0627\u0644\u0645\u0633\u0627\u0639\u062f\u0629 \u0641\u064a \u0627\u0644\u0633\u064a\u0637\u0631\u0629 \u0639\u0644\u0649 \u0634\u062f\u0629 \u0627\u0644\u0645\u0631\u0636\u060c \u0648\u0642\u062f \u064a\u0645\u0646\u062d \u0628\u0639\u0636 \u0627\u0644\u0645\u0631\u0636\u0649 \u0641\u062a\u0631\u0629 \u0623\u0637\u0648\u0644 \u062e\u0627\u0644\u064a\u0629 \u0645\u0646 \u0627\u0644\u0645\u0631\u0636.\u0648\u0645\u0639 \u0630\u0644\u0643\u060c \u0642\u062f \u062a\u062e\u062a\u0644\u0641 \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0628\u0639\u062f \u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0639\u062a\u0645\u0627\u062f\u0627\u064b \u0639\u0644\u0649 \u0639\u062f\u0629 \u0639\u0648\u0627\u0645\u0644\u060c \u0645\u062b\u0644 \u0646\u0648\u0639 \u0627\u0644\u0633\u0631\u0637\u0627\u0646\u060c \u0648\u0645\u0631\u062d\u0644\u0629 \u0627\u0644\u0645\u0631\u0636\u060c \u0648\u0643\u0645\u064a\u0629 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0633\u0631\u0637\u0627\u0646\u064a\u0629 \u0641\u064a \u0627\u0644\u062c\u0633\u0645\u060c \u0648\u0627\u0644\u062d\u0627\u0644\u0629 \u0627\u0644\u0635\u062d\u064a\u0629 \u0627\u0644\u0639\u0627\u0645\u0629 \u0644\u0644\u0645\u0631\u064a\u0636\u060c \u0648\u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u0627\u0644\u062c\u0647\u0627\u0632 \u0627\u0644\u0645\u0646\u0627\u0639\u064a\u060c \u0648\u0627\u0644\u0645\u0636\u0627\u0639\u0641\u0627\u062a \u0627\u0644\u0645\u062d\u062a\u0645\u0644\u0629 \u0627\u0644\u062a\u064a \u0642\u062f \u062a\u062d\u062f\u062b \u0628\u0639\u062f \u0627\u0644\u0639\u0644\u0627\u062c.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
\u0641\u064a \u0627\u0644\u0648\u0642\u062a \u0627\u0644\u062d\u0627\u0644\u064a\u060c \u064a\u064f\u0633\u062a\u062e\u062f\u0645 \u0639\u0644\u0627\u062c \u0627\u0644\u062e\u0644\u0627\u064a\u0627 CAR-T \u0644\u0639\u0644\u0627\u062c \u0628\u0639\u0636 \u0623\u0646\u0648\u0627\u0639 \u0633\u0631\u0637\u0627\u0646\u0627\u062a \u0627\u0644\u062f\u0645 \u0648\u0627\u0644\u0623\u0648\u0631\u0627\u0645 \u0627\u0644\u0644\u0645\u0641\u0627\u0648\u064a\u0629. \u0648\u0639\u0627\u062f\u0629\u064b \u0645\u0627 \u064a\u062a\u0645 \u0627\u0644\u0646\u0638\u0631 \u0641\u064a \u0647\u0630\u0627 \u0627\u0644\u0639\u0644\u0627\u062c \u0644\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u064a\u0646 \u0644\u0627 \u064a\u0633\u062a\u062c\u064a\u0628\u0648\u0646 \u0644\u0644\u0639\u0644\u0627\u062c\u0627\u062a \u0627\u0644\u0642\u064a\u0627\u0633\u064a\u0629\u060c \u0623\u0648 \u0627\u0644\u0630\u064a\u0646 \u0639\u0627\u062f \u0644\u062f\u064a\u0647\u0645 \u0627\u0644\u0645\u0631\u0636 \u0628\u0639\u062f \u0627\u0644\u0639\u0644\u0627\u062c\u060c \u0648\u0630\u0644\u0643 \u0644\u062a\u0648\u0641\u064a\u0631 \u062e\u064a\u0627\u0631 \u0639\u0644\u0627\u062c\u064a \u0625\u0636\u0627\u0641\u064a \u0644\u0647\u0645.<\/p>
\u0648\u064a\u0639\u062a\u0645\u062f \u062a\u062d\u062f\u064a\u062f \u0645\u0627 \u0625\u0630\u0627 \u0643\u0627\u0646 \u0627\u0644\u0645\u0631\u064a\u0636 \u0645\u0646\u0627\u0633\u0628\u0627\u064b \u0644\u0639\u0644\u0627\u062c \u0627\u0644\u062e\u0644\u0627\u064a\u0627 CAR-T \u0639\u0644\u0649 \u0639\u062f\u0629 \u0639\u0648\u0627\u0645\u0644\u060c \u0645\u0646\u0647\u0627 \u0646\u0648\u0639 \u0627\u0644\u0633\u0631\u0637\u0627\u0646\u060c \u0648\u0645\u0631\u062d\u0644\u0629 \u0627\u0644\u0645\u0631\u0636\u060c \u0648\u0627\u0644\u0639\u0644\u0627\u062c\u0627\u062a \u0627\u0644\u0633\u0627\u0628\u0642\u0629 \u0627\u0644\u062a\u064a \u062a\u0644\u0642\u0627\u0647\u0627 \u0627\u0644\u0645\u0631\u064a\u0636\u060c \u0648\u0627\u0644\u062d\u0627\u0644\u0629 \u0627\u0644\u0635\u062d\u064a\u0629 \u0627\u0644\u0639\u0627\u0645\u0629 \u0644\u0647. \u0648\u064a\u0642\u0648\u0645 \u0627\u0644\u0637\u0628\u064a\u0628 \u0628\u062a\u0642\u064a\u064a\u0645 \u0645\u062f\u0649 \u0645\u0644\u0627\u0621\u0645\u0629 \u0627\u0644\u0639\u0644\u0627\u062c \u0644\u0643\u0644 \u062d\u0627\u0644\u0629 \u0628\u0634\u0643\u0644 \u0641\u0631\u062f\u064a.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
\u064a\u0645\u0643\u0646 \u062a\u0644\u062e\u064a\u0635 \u0627\u0644\u0641\u0631\u0642 \u0628\u064a\u0646 \u0639\u0644\u0627\u062c \u0627\u0644\u062e\u0644\u0627\u064a\u0627 CAR-T \u0648\u0639\u0644\u0627\u062c\u0627\u062a \u0627\u0644\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062a\u0642\u0644\u064a\u062f\u064a\u0629 \u0643\u0645\u0627 \u064a\u0644\u064a:<\/p>
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